Fig. 2. LRRC8/VRACs and the cellular oxidative status. (A) Various stimuli lead to ROS increase that triggers VRACs activation. Abbreviations: AT1: Angiotensin receptor 1, DPI: Diphenyleneiodonium, EGF: Epithelial Growth Factor, NAC: N-acetyl cysteine, NOX: NADPH Oxidase, STS: Staurosporine; TM: Tunicamycin. (B) Regulation of LRRC8/VRACs current by oxidizing and reducing agents depending on the subunit's composition of VRAC. Adapted from [92]. (C) LRRC8/VRAC-dependent GSH efflux contributes to the cellular antioxidant system. Abbreviations: GSH: Glutathione, KD: Knockdown, TGF-β1: transforming Growth Factor.